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CS-W001157 4
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3-Chloro-4-((3-fluorobenzyl)oxy)aniline Lapatinib Impurity

  • CAS No. 202197-26-0

  • Cat. No. CS-0204130
  • Purity≥97%
  • MDL No.MFCD06809822

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4-((3-fluorobenzyl)oxy)aniline Lapatinib Impurity|CS-0204130

Structure of 202197-26-0

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General Information

  • CAS No. 202197-26-0
  • Cat. No. CS-0204130
  • Purity ≥97%
  • MDL No. MFCD06809822
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₁ClFNO
  • Molecular Weight 251.68
  • Synonym(s) 4-(3-fluorobenzyloxy)-3-chlorobenzenamine
  • SMILES NC1=CC=C(OCC2=CC=CC(F)=C2)C(Cl)=C1

Synthesis

  • Route1

    References

    • Lackey, Karen Elizabeth; Spector, Neil; Wood lll, Edgar Raymond; Xia, Wenle Patent: US2004/53946 A1, 2004 ;
  • Route2
    • null|null
      878018-19-0
    • ~92%
    • 3-Chloro-4-((3-fluorobenzyl)oxy)aniline Lapatinib Impurity|CS-0204130
      202197-26-0

    References

    • BAYER HEALTHCARE AG Patent: US2010/298297 A1, 2010 ; Location in patent: Page/Page column 14 ;
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   3.6403
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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