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CS-W001157 4
Total: USD 88.00

4-(1,3-Dioxolan-2-yl)piperidine

  • CAS No. 202062-80-4

  • Cat. No. CS-0480031
  • Purity≥98%
  • MDL No.MFCD16547635

*For research and further manufacturing use only, not for direct human use.

4-(1,3-Dioxolan-2-yl)piperidine|CS-0480031

Structure of 202062-80-4

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General Information

  • CAS No. 202062-80-4
  • Cat. No. CS-0480031
  • Purity ≥98%
  • MDL No. MFCD16547635
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅NO₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES N1CCC(CC1)C2OCCO2

Description

4-(1,3-Dioxolan-2-yl)piperidine features a stabilized dioxolane ring fused to the piperidine nitrogen, delivering enhanced moisture tolerance and thermal resilience. This protected amine integrates seamlessly into multistep syntheses, enabling efficient access to complex heterocycles under standard conditions. The dioxolane moiety facilitates selective transformations while minimizing side reactivity.

Application

4-(1,3-Dioxolan-2-yl)piperidine serves as a stable, bench-ready synthon for the introduction of piperidine scaffolds bearing a masked aldehyde functionality. The 1,3-dioxolane ring enables selective deprotection under mild acidic conditions, facilitating downstream transformations such as reductive amination or nucleophilic addition. Its functional group tolerance and ease of purification make it a practical building block in medicinal chemistry workflows for constructing bioactive heterocycles and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.49
  • LogP   0.3589
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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