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Structure of 201929-84-2
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Ethyl 5-(trifluoromethyl)indole-2-carboxylate features a trifluoromethyl group at the 5-position of the indole ring, enhancing electron-withdrawing character and metabolic stability. This robust scaffold integrates readily into pharmaceutical intermediates, particularly in kinase inhibitor and bioactive heterocycle synthesis, under standard coupling conditions.
Ethyl 5-(trifluoromethyl)indole-2-carboxylate serves as a versatile building block for constructing indole-based scaffolds in medicinal chemistry. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the ester functionality enables straightforward derivatization via hydrolysis, reduction, or coupling reactions. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for iterative synthesis of bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H317
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Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: