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6-(6-Aminohexanamido)hexanoic acid

  • CAS No. 2014-58-6

  • Cat. No. CS-0160596
  • Molecule weight244.33
  • Purity≥97%
  • MDL No.MFCD13213194

*For research and further manufacturing use only, not for direct human use.

6-(6-Aminohexanamido)hexanoic acid|CS-0160596

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General Information

  • CAS No. 2014-58-6
  • Cat. No. CS-0160596
  • Purity ≥97%
  • MDL No. MFCD13213194
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₄N₂O₃
  • Molecular Weight 244.33
  • Synonym(s) N-(6'-Aminocaproyl)-6-aminocaproic Acid
  • SMILES O=C(O)CCCCCNC(CCCCCN)=O

Description

6-(6-Aminohexanamido)hexanoic acid features a bifunctional architecture with terminal amine and carboxylic acid groups separated by a six-carbon aliphatic chain. This structure enables efficient conjugation in bioconjugation workflows, particularly for linking biomolecules via amide bond formation. The molecule's flexibility and solubility support reliable integration into peptide- and polymer-based systems under standard conditions.

Application

6-(6-Aminohexanamido)hexanoic acid serves as a versatile bifunctional building block for peptide and polymer synthesis, enabling site-specific conjugation via amine and carboxylic acid handles. Its aliphatic spacer provides flexibility and solubility, facilitating efficient coupling reactions with minimal steric hindrance. The compound exhibits excellent bench stability and ease of purification, making it well-suited for solid-phase and solution-phase workflows in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • Benzyl 6-(6-(((benzyloxy)carbonyl)amino)hexanamido)hexanoate|CS-0539306
      2899-61-8
    • ~98%
    • In-stock
      6-(6-Aminohexanamido)hexanoic acid|CS-0160596
      2014-58-6

    References

    • Leonard, Nicholas M.; Brunckova, Jarmila Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 9169 - 9174
  • Route2
    • null|null
      49701-55-5
    • ~%
    • In-stock
      6-(6-Aminohexanamido)hexanoic acid|CS-0160596
      2014-58-6

    References

    • West Faserforsch. Textiltech., 1954 , vol. 5, p. 145,153 Full Text Show Details Zahn; Hildebrand Chemische Berichte, 1957 , vol. 90, p. 320,328
  • Route3

    References

    • West Faserforsch. Textiltech., 1954 , vol. 5, p. 145,153

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   92.42
  • LogP   1.2667
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   11

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