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CS-W001157 4
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2-[Bis[(1,1-dimethylethoxy)carbonyl]amino]-,methyl ester-2-Propenoic acid

  • CAS No. 201338-62-7

  • Cat. No. CS-0620558
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-[Bis[(1,1-dimethylethoxy)carbonyl]amino]-,methyl ester-2-Propenoic acid|CS-0620558

Structure of 201338-62-7

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General Information

  • CAS No. 201338-62-7
  • Cat. No. CS-0620558
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₃NO₆
  • Molecular Weight 301.34
  • Synonym(s) None
  • SMILES C=C(N(C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)C(OC)=O

Description

This methyl ester of 2-[bis[(1,1-dimethylethoxy)carbonyl]amino]-2-propenoic acid features a sterically hindered carbamate-protected amine group flanked by an electron-deficient enoate system. The di-tert-butoxycarbonyl (DTB) moiety provides exceptional bench stability and moisture tolerance, enabling straightforward handling in synthetic workflows. This protected aminoacrylate derivative integrates readily into peptide-like architectures and serves as a key building block for conjugation strategies requiring orthogonal deprotection.

Application

2-[Bis[(1,1-dimethylethoxy)carbonyl]amino]-2-propenoic acid methyl ester serves as a stable, bench-ready building block for peptide synthesis and heterocyclic scaffolds. Its tert-butoxycarbonyl (Boc) groups provide robust protection of amine functionalities, enabling orthogonal deprotection in standard workflows. The acrylate moiety facilitates conjugate addition reactions and serves as a versatile handle for Michael-type additions or polymerization. Designed for ease of handling and purification, it supports scalable synthesis and is compatible with common reaction conditions in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   82.14
  • LogP   2.8453
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   2

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