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CS-W001157 4
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H-D-Thr(tBu)-OH

  • CAS No. 201274-81-9

  • Cat. No. CS-0043728
  • Purity≥97%
  • MDL No.MFCD00171400

*For research and further manufacturing use only, not for direct human use.

H-D-Thr(tBu)-OH|CS-0043728

Structure of 201274-81-9

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General Information

  • CAS No. 201274-81-9
  • Cat. No. CS-0043728
  • Purity ≥97%
  • MDL No. MFCD00171400
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₇NO₃
  • Molecular Weight 175.23
  • Synonym(s) None
  • SMILES N[C@H]([C@@H](OC(C)(C)C)C)C(O)=O

Description

H-D-Thr(tBu)-OH is a protected, non-natural amino acid derivative featuring a tert-butyl group at the β-position, offering enhanced stability and steric shielding. This configuration enables selective incorporation into peptide sequences under standard coupling conditions, facilitating the synthesis of conformationally restricted analogs with improved metabolic resilience.

Application

H-D-Thr(tBu)-OH serves as a stable, bench-ready building block for the synthesis of peptidomimetics and bioactive oligomers. The tert-butyl-protected hydroxyl group enables orthogonal functionalization in complex sequences, while the D-threonine backbone provides stereochemical control in constrained peptide architectures. This derivative facilitates efficient coupling reactions and is compatible with standard solid-phase and solution-phase protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   0.6019
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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