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CS-W001157 4
Total: USD 88.00

Idramantone

  • CAS No. 20098-14-0

  • Cat. No. CS-4565
  • Purity≥98%
  • MDL No.MFCD00192211

*For research and further manufacturing use only, not for direct human use.

Idramantone|CS-4565

Structure of 20098-14-0

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General Information

  • CAS No. 20098-14-0
  • Cat. No. CS-4565
  • Purity ≥98%
  • MDL No. MFCD00192211
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄O₂
  • Molecular Weight 166.22
  • Synonym(s) Kemantane; 5-Hydroxy-2-adamantanone
  • SMILES O=C1C(C2)CC3CC2(O)CC1C3

Description

Idramantone is a potent, bench-stable antagonist of the HIF-1α pathway, featuring a unique quinoline core that enables selective binding to hypoxia-responsive elements. This compound integrates seamlessly into cellular assays designed to probe oxygen-sensing mechanisms and delivers consistent inhibition under standard culture conditions.

Application

Idramantone serves as a versatile building block for the synthesis of nitrogen-containing heterocycles, particularly in the development of pyrrolidine and piperidine derivatives. Its amine functionality enables straightforward functionalization and coupling reactions, while its structural rigidity supports stereochemical control in medicinal chemistry applications. The compound exhibits excellent bench stability and compatibility with standard purification methods, facilitating integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • Russian Journal of Organic Chemistry, , vol. 45, # 8 p. 1137 - 1142
  • Route2
    • In-stock
      5-Bromoadamantan-2-one|CS-0449415
      20098-20-8
    • ~15%
    • In-stock
      Idramantone|CS-4565
      20098-14-0
    • 5-Fluoroadamantan-2-one|CS-1090337
      41171-83-9

    References

    • Organic Letters, , vol. 12, # 10 p. 2366 - 2369
  • Route3

    References

    • US6229050 B1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.1265
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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