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2-Piperidinoethyl chloride hydrochloride

  • CAS No. 2008-75-5

  • Cat. No. CS-B0962
  • Purity≥97%
  • MDL No.MFCD00012837

*For research and further manufacturing use only, not for direct human use.

2-Piperidinoethyl chloride hydrochloride|CS-B0962

Structure of 2008-75-5

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General Information

  • CAS No. 2008-75-5
  • Cat. No. CS-B0962
  • Purity ≥97%
  • MDL No. MFCD00012837
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅Cl₂N
  • Molecular Weight 184.11
  • Synonym(s) N-(2-Chloroethyl)piperidine hydrochloride; N-(2-Chloroethyl)piperidine HCl; 2-Piperidinoethyl chloride hydrochloride
  • SMILES ClCCN1CCCCC1.[H]Cl

Description

2-Piperidinoethyl chloride hydrochloride delivers a reactive chloroalkyl handle for conjugation workflows. This bench-stable, moisture-tolerant reagent features a primary amine-bearing chain that facilitates efficient coupling to carboxylic acids and other nucleophiles under mild conditions.

Application

2-Piperidinoethyl chloride hydrochloride serves as a versatile alkylating agent in synthetic organic chemistry, enabling efficient functionalization of nucleophiles under mild conditions. Its well-documented reactivity facilitates the construction of piperidine-containing scaffolds common in medicinal chemistry. The hydrochloride salt ensures excellent bench stability and ease of handling, while its compatibility with diverse functional groups supports straightforward purification and integration into multi-step syntheses.

Synthesis

  • Route1

    References

    • Neurochem (International) Limited Patent: US2006/223855 A1, 2006 ; Location in patent: Page/Page column 160-161 ;
  • Route2
    • null|null
      110-89-4
    • null|null
      107-07-3
    • ~58%
    • In-stock
      2-Piperidinoethyl chloride hydrochloride|CS-B0962
      2008-75-5

    References

    • CHINA PHARMACEUTICAL UNIVERSITY; Xiang, Hua; Wang, Tianlin; Xiao, Hong; You, Qidong; Yao, Yao; Li, Xiaobo; Liao, Qingjiang Patent: US2013/85140 A1, 2013 ; Location in patent: Paragraph 0052; 0053 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2928
Class : 6.1 (8)
Packing Group : Ⅱ
Hazard Statements : H300-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   2.1329
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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