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CS-W001157 4
Total: USD 88.00

2,2-Difluoro-2-(thiazol-5-yl)acetic acid

  • CAS No. 2007426-87-9

  • Cat. No. CS-0527668
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,2-Difluoro-2-(thiazol-5-yl)acetic acid|CS-0527668

Structure of 2007426-87-9

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General Information

  • CAS No. 2007426-87-9
  • Cat. No. CS-0527668
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃F₂NO₂S
  • Molecular Weight 179.14
  • Synonym(s) None
  • SMILES O=C(O)C(F)(F)C1=CN=CS1

Description

This difluorinated acetic acid derivative features a thiazol-5-yl group that enhances electron-withdrawing character and metabolic stability. The geminal difluoro substitution imparts strong polarity and resistance to enzymatic degradation, making it valuable for synthesizing bioactive molecules in medicinal chemistry and agrochemical research.

Application

2,2-Difluoro-2-(thiazol-5-yl)acetic acid serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds. Its difluoromethyl group imparts enhanced metabolic stability and modulates lipophilicity, while the thiazole moiety provides a versatile handle for further derivatization. The compound exhibits good bench stability and facilitates efficient coupling reactions, making it well-suited for use in the synthesis of bioactive molecules and API intermediates.

Safety Information

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.3195
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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