2’-O,4’-C-Methyleneuridine

Name: 2’-O,4’-C-Methyleneuridine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 200435-92-3
Cat. No. CS-0089190
Purity≥98%
MDL No.MFCD12911820

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 200435-92-3

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Description

2’-O,4’-C-Methyleneuridine features a rigid bicyclic sugar scaffold that enhances nuclease resistance and improves binding affinity in oligonucleotide therapeutics. This modified uridine analog integrates seamlessly into RNA sequences, offering enhanced stability under physiological conditions while maintaining efficient base pairing.

Application

2’-O,4’-C-Methyleneuridine serves as a key nucleoside building block for the synthesis of modified oligonucleotides, offering enhanced nuclease resistance and improved binding affinity. Its locked ribose conformation stabilizes the C3′-endo sugar pucker, facilitating precise duplex formation. The methylene bridge between the 2′-oxygen and 4′-carbon confers excellent bench stability and compatibility with standard phosphoramidite chemistry, enabling efficient incorporation into antisense and siRNA constructs.

General Information

CAS No. 200435-92-3
Cat. No. CS-0089190
Purity ≥98%
MDL No. MFCD12911820
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₂N₂O₆
Molecular Weight 256.21
Synonym(s) None
SMILES OC[C@]12[C@@H](O)[C@@H](OC2)[C@H](N(C(N3)=O)C=CC3=O)O1

Computational Chemistry Data

TPSA 113.78
LogP -2.4438
H_Acceptors 7
H_Donors 3
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Nucleosides & Nucleotides Other Protective Nucleosides

Chemical Biology Nucleic Acid Chemistry Protected Nucleosides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

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2’-O,4’-C-Methyleneuridine

CAS No. 200435-92-3

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