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CS-W001157 4
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(1-Methyl-1H-benzo[d]imidazol-2-yl)methanamine

  • CAS No. 20028-40-4

  • Cat. No. CS-0151132
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(1-Methyl-1H-benzo[d]imidazol-2-yl)methanamine|CS-0151132

Structure of 20028-40-4

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General Information

  • CAS No. 20028-40-4
  • Cat. No. CS-0151132
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁N₃
  • Molecular Weight 161.20
  • Synonym(s) (1-Methyl-1h-benzimidazol-2-yl)methylamine
  • SMILES CN1C2=C(C=CC=C2)N=C1CN

Description

This bench-stable amine features a methyl-substituted benzimidazole core, offering enhanced solubility and nucleophilicity. The pendant primary amine group enables efficient coupling in bioconjugation and ligand synthesis, while the fused heterocyclic system provides rigidity and metabolic stability for applications in medicinal chemistry and materials science.

Application

(1-Methyl-1H-benzo[d]imidazol-2-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its benzimidazole core exhibits robust bench stability and tolerates diverse functional groups, facilitating downstream derivatization via nucleophilic substitution or reductive amination. The primary amine functionality supports conjugation strategies and salt formation, enhancing solubility and formulation potential in API development workflows.

Synthesis

  • Route1
    • (1-Methyl-1H-benzo[d]imidazol-2-yl)methanamine dihydrochloride|CS-0071981
      53332-79-9
    • ~%
    • In-stock
      (1-Methyl-1H-benzo[d]imidazol-2-yl)methanamine|CS-0151132
      20028-40-4

    References

    • EP1135374 B1, ; Page/Page column 37 ;
  • Route2

    References

    • Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 29, # 5 p. 567 - 574 Khimiya Geterotsiklicheskikh Soedinenii, , # 5 p. 664 - 672
  • Route3
    • null|null
      1442637-90-2
    • ~90%
    • In-stock
      (1-Methyl-1H-benzo[d]imidazol-2-yl)methanamine|CS-0151132
      20028-40-4

    References

    • Chemistry - A European Journal, , vol. 19, # 19 p. 6067 - 6079

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   1.032
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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