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5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine

  • CAS No. 2002-04-2

  • Cat. No. CS-M3225
  • Purity≥97%
  • MDL No.MFCD00473692

*For research and further manufacturing use only, not for direct human use.

5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine|CS-M3225

Structure of 2002-04-2

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General Information

  • CAS No. 2002-04-2
  • Cat. No. CS-M3225
  • Purity ≥97%
  • MDL No. MFCD00473692
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆N₄S
  • Molecular Weight 178.21
  • Synonym(s) 2-Amino-5-(4-pyridinyl)-1,3,4-thiadiazole; 5-(4-Pyridyl)-2-amino-1,3,4-thiadiazole; 5-(4-Pyridyl)-1,3,4-thiadiazol-2-amine
  • SMILES NC1=NN=C(S1)C2=CC=NC=C2

Description

5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine features a pyridyl-substituted thiadiazole core with a pendant amine group, enabling coordination in metal complexes and integration into functional materials. This heterocyclic scaffold exhibits enhanced solubility and stability under standard conditions, supporting its use in synthetic organic chemistry and medicinal research.

Application

5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling rapid access to bioactive scaffolds through its reactive amine functionality and electron-deficient thiadiazole core. Its stability under standard synthetic conditions and compatibility with common coupling reactions facilitate efficient derivatization for drug discovery applications.

Synthesis

  • Route1

    References

    • VERTEX PHARMACEUTICALS INCORPORATED Patent: WO2004/41813 A1, 2004 ; Location in patent: Page 102-103 ; WO 2004/041813 A1
  • Route2

    References

    • Yu, Peng; Hu, Jun; Zhou, Tao-Yu; Wang, Peng; Xu, Yan-Hua Journal of Chemical Research, 2011 , vol. 35, # 12 p. 703 - 706
  • Route3
    • Semicarbazide, 1-isonicotinoyl-3-thio-|CS-0014229
      14397-24-1
    • ~%
    • In-stock
      5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine|CS-M3225
      2002-04-2

    References

    • Farmaco, Edizione Scientifica, , vol. 13, p. 187,196 Yakugaku Zasshi, , vol. 74, p. 951 Chem.Abstr., , p. 10938

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   64.69
  • LogP   1.1823
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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