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CS-W001157 4
Total: USD 88.00

H-Arg(Pbf)-OH

  • CAS No. 200115-86-2

  • Cat. No. CS-W022735
  • Purity≥97%
  • MDL No.MFCD00236797

*For research and further manufacturing use only, not for direct human use.

H-Arg(Pbf)-OH|CS-W022735

Structure of 200115-86-2

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General Information

  • CAS No. 200115-86-2
  • Cat. No. CS-W022735
  • Purity ≥97%
  • MDL No. MFCD00236797
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₃₀N₄O₅S
  • Molecular Weight 426.53
  • Synonym(s) (E)-N~5~-(amino{[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]amino}methylidene)-L-ornithine
  • SMILES O=C(O)[C@@H](N)CCCNC(NS(=O)(C1=C(C)C(C)=C(OC(C)(C)C2)C2=C1C)=O)=N

Description

H-Arg(Pbf)-OH is a protected arginine derivative featuring a Pbf (para-benzoylphenyl) group at the guanidino nitrogen, ensuring stability during peptide synthesis. This residue integrates seamlessly into solid-phase and solution-phase workflows, offering high solubility and minimal side reactions. The N-terminal amine remains free for coupling, enabling efficient chain elongation in complex peptide sequences.

Application

H-Arg(Pbf)-OH serves as a robust, bench-stable building block for solid-phase peptide synthesis, enabling efficient incorporation of arginine residues with high coupling yields. The Pbf (pentabromobenzoyl) group provides excellent orthogonality and stability under standard deprotection conditions, facilitating selective side-chain manipulation. Its compatibility with diverse coupling reagents and minimal epimerization make it ideal for synthesizing complex peptides and peptidomimetics.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   154.6
  • LogP   1.32013
  • H_Acceptors   6
  • H_Donors   5
  • Rotatable_Bonds   7

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