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CS-W001157 4
Total: USD 88.00

2-Aminomethylpyrazine

  • CAS No. 20010-99-5

  • Cat. No. CS-W018519
  • Purity≥96%
  • MDL No.MFCD00673149

*For research and further manufacturing use only, not for direct human use.

2-Aminomethylpyrazine|CS-W018519

Structure of 20010-99-5

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General Information

  • CAS No. 20010-99-5
  • Cat. No. CS-W018519
  • Purity ≥96%
  • MDL No. MFCD00673149
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃
  • Molecular Weight None
  • Synonym(s) 1-(pyrazin-2-yl)methanamine
  • SMILES NCC1=NC=CN=C1

Description

2-Aminomethylpyrazine delivers a bifunctional scaffold combining a pyrazine core with a reactive aminomethyl group, enabling straightforward conjugation in synthetic medicinal chemistry. This bench-stable heterocycle integrates readily into drug discovery libraries and serves as a key building block for targeted bioconjugates.

Application

2-Aminomethylpyrazine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrazine-based pharmacophores. The primary amine functionality facilitates straightforward derivatization via amidation, alkylation, and reductive amination, while the pyrazine core offers enhanced metabolic stability and favorable physicochemical properties. Its bench-stable nature and compatibility with standard purification protocols make it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • Pyrazinecarbonitrile|CS-0229559
      19847-12-2
    • ~96%
    • In-stock
      2-Aminomethylpyrazine|CS-W018519
      20010-99-5

    References

    • SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; JIANGSU HENGRUI MEDICINE CO., LTD. Patent: US2012/65209 A1, 2012 ; Location in patent: Page/Page column 9 ;
  • Route2
    • null|null
      20584-30-9
    • ~69%
    • In-stock
      2-Aminomethylpyrazine|CS-W018519
      20010-99-5

    References

    • XENON PHARMACEUTICALS INC.; LIU, Shifeng; FOCKEN, Thilo; CHAHAL, Navjot; ZHANG, Zaihui; OBALLA, Renata, Marcella; FONAREV, Julia Patent: WO2013/64984 A1, 2013 ; Location in patent: Page/Page column 65 ; WO 2013/064984 A1
  • Route3
    • null|null
      39204-47-2
    • ~%
    • In-stock
      2-Aminomethylpyrazine|CS-W018519
      20010-99-5

    References

    • WO2013/64984 A1, ; WO 2013/064984 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   -0.0647
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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