Fmoc-D-Phe(2-F)-OH

Name: Fmoc-D-Phe(2-F)-OH
Brand: ChemScene
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CAS No. 198545-46-9
Cat. No. CS-W011690
Purity≥95%
MDL No.MFCD00672553

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 198545-46-9

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General Information

CAS No. 198545-46-9
Cat. No. CS-W011690
Purity ≥95%
MDL No. MFCD00672553
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₀FNO₄
Molecular Weight 405.42
Synonym(s) None
SMILES O=C([C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O)CC4=CC=CC=C4F)O

Description

Fmoc-D-Phe(2-F)-OH features a fluorinated phenyl ring at the ortho position, enhancing electron-withdrawing character and metabolic stability. This D-amino acid derivative integrates seamlessly into peptide sequences, offering improved proteolytic resistance and structural rigidity in synthetic applications.

Application

Fmoc-D-Phe(2-F)-OH serves as a valuable building block in peptide synthesis, offering enhanced metabolic stability and modulated hydrophobicity through the 2-fluorophenyl substitution. The Fmoc group enables efficient solution-phase and solid-phase coupling with minimal epimerization, while the D-configured amino acid provides stereochemical control. This derivative facilitates the incorporation of fluorinated aromatic residues into bioactive peptides, supporting structural diversification in medicinal chemistry campaigns.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 75.63
LogP 4.3601
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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Fmoc-D-Phe(2-F)-OH

CAS No. 198545-46-9

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