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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((diphenyl(p-tolyl)methyl)amino)hexanoic acid

  • CAS No. 198544-94-4

  • Cat. No. CS-0153098
  • Molecule weight624.77
  • Purity≥98%
  • MDL No.MFCD26793593

*For research and further manufacturing use only, not for direct human use.

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((diphenyl(p-tolyl)methyl)amino)hexanoic acid|CS-0153098

Structure of 198544-94-4

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General Information

  • CAS No. 198544-94-4
  • Cat. No. CS-0153098
  • Purity ≥98%
  • MDL No. MFCD26793593
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₁H₄₀N₂O₄
  • Molecular Weight 624.77
  • Synonym(s) N-Alpha-Fmoc-N-Epsilon-(4-Methyltrityl)-D-Lysine
  • SMILES CC1=CC=C(C(C2=CC=CC=C2)(NCCCC[C@@H](NC(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O)C(O)=O)C6=CC=CC=C6)C=C1

Description

This chiral fluorenonyl-protected amino acid derivative features a sterically hindered side chain and a bench-stable carbamate group, enabling efficient incorporation into peptide synthesis workflows. The diphenyl(p-tolyl)methyl moiety provides robust protection, while the (R)-configuration ensures stereoselective coupling under standard conditions.

Application

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((diphenyl(p-tolyl)methyl)amino)hexanoic acid serves as a versatile chiral building block for peptide synthesis, enabling the construction of complex amino acid scaffolds with high stereochemical fidelity. The Fmoc group ensures efficient protection and orthogonal deprotection, while the diphenyl(p-tolyl)methyl (Dmp) amine moiety provides robust stability and facilitates selective cleavage under mild acidic conditions. This compound exhibits excellent bench stability, compatibility with standard coupling protocols, and ease of purification, making it well-suited for both academic and industrial-scale peptide assembly workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   87.66
  • LogP   8.03872
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   13

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