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CS-W001157 4
Total: USD 88.00

3-Methylpyrazin-2-amine

  • CAS No. 19838-08-5

  • Cat. No. CS-W003560
  • Purity≥98%
  • MDL No.MFCD08705770

*For research and further manufacturing use only, not for direct human use.

3-Methylpyrazin-2-amine|CS-W003560

Structure of 19838-08-5

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General Information

  • CAS No. 19838-08-5
  • Cat. No. CS-W003560
  • Purity ≥98%
  • MDL No. MFCD08705770
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃
  • Molecular Weight 109.13
  • Synonym(s) Pyrazinamine, 3-Methyl-
  • SMILES CC(N=CC=N1)=C1N

Description

3-Methylpyrazin-2-amine delivers a pyrazine core with enhanced electron density via a methyl group at the 3-position and a primary amine at the 2-position. This combination enables direct incorporation into heterocyclic scaffolds, facilitating rapid access to bioactive molecules in medicinal chemistry. The compound exhibits bench-stable handling characteristics and integrates readily under standard coupling conditions.

Application

3-Methylpyrazin-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of bioactive molecules through established coupling and functionalization reactions. Its pyrazine core provides enhanced metabolic stability and favorable physicochemical properties, while the amine functionality offers a direct handle for derivatization. Bench-stable and readily purified, it functions effectively in standard amide coupling, Suzuki-Miyaura, and electrophilic substitution protocols.

Synthesis

  • Route1

    References

    • WO2009/29625 A1, ; Page/Page column 67 ; WO 2009/029625 A1
  • Route2

    References

    • Journal of Heterocyclic Chemistry, , vol. 17, p. 143 - 147

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.36722
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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