Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Fluoro-3-methoxybenzonitrile

  • CAS No. 198203-94-0

  • Cat. No. CS-0097743
  • Purity≥98%
  • MDL No.MFCD09839223

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-3-methoxybenzonitrile|CS-0097743

Structure of 198203-94-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 198203-94-0
  • Cat. No. CS-0097743
  • Purity ≥98%
  • MDL No. MFCD09839223
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆FNO
  • Molecular Weight 151.14
  • Synonym(s) Benzonitrile, 2-fluoro-3-methoxy- (9CI)
  • SMILES N#CC1=CC=CC(OC)=C1F

Description

2-Fluoro-3-methoxybenzonitrile features a strategically positioned nitrile group flanked by fluorine and methoxy substituents, delivering enhanced electron-withdrawing character and improved solubility in polar organic media. This combination enables efficient incorporation into complex heterocycles and pharmaceutical intermediates under standard coupling conditions.

Application

2-Fluoro-3-methoxybenzonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the ortho-fluorine site via nucleophilic substitution. The nitrile and methoxy groups provide orthogonal handles for downstream derivatization, while the compound exhibits excellent bench stability and ease of purification. Its compatibility with palladium-catalyzed cross-coupling reactions facilitates efficient access to complex aromatic scaffolds.

Synthesis

  • Route1
    • 2-Fluoro-3-methoxybenzamide|CS-0872450
      198204-64-7
    • ~51%
    • In-stock
      2-Fluoro-3-methoxybenzonitrile|CS-0097743
      198203-94-0

    References

    • Bridges, Alexander J.; Zhou, Hairong Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1163 - 1172
  • Route2
    • null|null
      74-83-9
    • In-stock
      2-Fluoro-3-hydroxybenzonitrile|CS-0157218
      1000339-24-1
    • ~%
    • In-stock
      2-Fluoro-3-methoxybenzonitrile|CS-0097743
      198203-94-0

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4599 - 4604
  • Route3

    References

    • Journal of Heterocyclic Chemistry, , vol. 34, # 4 p. 1163 - 1172

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   33.02
  • LogP   1.70598
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-Fluoro-3-methoxybenzonitrile sigma2-Fluoro-3-methoxybenzonitrile manufacturer2-Fluoro-3-methoxybenzonitrile price2-Fluoro-3-methoxybenzonitrile structure2-Fluoro-3-methoxybenzonitrile SDSbuy 2-Fluoro-3-methoxybenzonitrile2-Fluoro-3-methoxybenzonitrile supplier2-Fluoro-3-methoxybenzonitrile uses2-Fluoro-3-methoxybenzonitrile molecular weightprice of 2-Fluoro-3-methoxybenzonitrile2-Fluoro-3-methoxybenzonitrile chemical name formula of 2-Fluoro-3-methoxybenzonitrile
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label