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CS-W001157 4
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2-(2-Chlorophenyl)ethan-1-ol

  • CAS No. 19819-95-5

  • Cat. No. CS-W017988
  • Purity≥98%
  • MDL No.MFCD00002888

*For research and further manufacturing use only, not for direct human use.

2-(2-Chlorophenyl)ethan-1-ol|CS-W017988

Structure of 19819-95-5

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General Information

  • CAS No. 19819-95-5
  • Cat. No. CS-W017988
  • Purity ≥98%
  • MDL No. MFCD00002888
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClO
  • Molecular Weight 156.61
  • Synonym(s) o-Chlorophenylmethylcarbinol
  • SMILES ClC1=CC=CC=C1CCO

Description

2-(2-Chlorophenyl)ethan-1-ol features a benzyl alcohol scaffold bearing a chlorinated phenyl ring, delivering enhanced lipophilicity and metabolic stability. This compound serves as a key intermediate in pharmaceutical synthesis, particularly for bioactive molecules requiring aromatic halogenation and hydroxyl functionality. Its bench-stable nature supports reliable handling under standard conditions.

Application

2-(2-Chlorophenyl)ethan-1-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically relevant scaffolds. Its benzylic alcohol functionality facilitates straightforward oxidation to the corresponding carboxylic acid or conversion to esters and ethers, while the ortho-chlorophenyl group provides favorable electronic and steric properties for downstream coupling reactions. The compound exhibits good bench stability and is compatible with standard purification techniques, making it a practical reagent for iterative synthesis workflows.

Synthesis

  • Route1

    References

    • Glennon; Salley Jr.; Steinsland; Nelson Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 678 - 683
  • Route2

    References

    • Chemistry - A European Journal, , vol. 5, # 4 p. 1320 - 1330
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 91, p. 6464 - 6470

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.8748
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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