4-Chloro-7-nitroquinazoline

Name: 4-Chloro-7-nitroquinazoline
Brand: ChemScene
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CAS No. 19815-17-9
Cat. No. CS-W002160
Purity≥97%
MDL No.MFCD00033667

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General Information

CAS No. 19815-17-9
Cat. No. CS-W002160
Purity ≥97%
MDL No. MFCD00033667
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₄ClN₃O₂
Molecular Weight 209.59
Synonym(s) 4-Chlor-7-nitro-chinazolin
SMILES O=[N+](C1=CC2=NC=NC(Cl)=C2C=C1)[O-]

Description

4-Chloro-7-nitroquinazoline features a fused bicyclic core with complementary electron-withdrawing groups at the 4-chloro and 7-nitro positions, enabling selective reactivity in cross-coupling and bioconjugation workflows. This bench-stable scaffold integrates readily into kinase inhibitor libraries and serves as a key intermediate for targeted covalent probe development under standard conditions.

Application

4-Chloro-7-nitroquinazoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions at the C4 position due to its activated halide. The electron-withdrawing nitro group at C7 enhances electrophilicity and facilitates nucleophilic substitution, while the quinazoline core provides a rigid scaffold for targeted drug discovery. Its bench-stable nature and compatibility with standard reaction conditions make it suitable for iterative synthesis of kinase inhibitors and other heterocyclic APIs.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

TPSA 68.92
LogP 2.1914
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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4-Chloro-7-nitroquinazoline

CAS No. 19815-17-9

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