2,4-Dichloro-7-nitroquinazoline

Name: 2,4-Dichloro-7-nitroquinazoline
Brand: ChemScene
Availability: InStock
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CAS No. 129112-65-8
Cat. No. CS-0141014
Purity≥95%
MDL No.MFCD18157742

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,4-Dichloro-7-nitroquinazoline|CS-0141014

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General Information

CAS No. 129112-65-8
Cat. No. CS-0141014
Purity ≥95%
MDL No. MFCD18157742
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₃Cl₂N₃O₂
Molecular Weight 244.03
Synonym(s) None
SMILES O=[N+](C1=CC2=NC(Cl)=NC(Cl)=C2C=C1)[O-]

Description

2,4-Dichloro-7-nitroquinazoline features a highly electron-deficient quinazoline core with dual chloro substituents at positions 2 and 4, enhancing reactivity for nucleophilic substitution. The para-nitro group at position 7 further increases electrophilicity, enabling efficient coupling in heterocyclic synthesis. This compound serves as a key scaffold for developing kinase inhibitors and advanced pharmaceutical intermediates under standard bench conditions.

Application

2,4-Dichloro-7-nitroquinazoline serves as a versatile building block in medicinal chemistry, enabling regioselective functionalization at the C2 and C4 positions via palladium-catalyzed cross-coupling reactions. Its electron-deficient quinazoline core enhances reactivity in nucleophilic substitution processes, while the nitro group provides a handle for reduction and downstream derivatization. The compound exhibits good bench stability and facilitates the construction of complex heterocyclic scaffolds relevant to kinase inhibitor development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 68.92
LogP 2.8448
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

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2,4-Dichloro-7-nitroquinazoline

CAS No. 129112-65-8

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