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CS-W001157 4
Total: USD 88.00

N-Methyl-2-fluoroaniline

  • CAS No. 1978-38-7

  • Cat. No. CS-W013511
  • Purity≥98%
  • MDL No.MFCD00028030

*For research and further manufacturing use only, not for direct human use.

N-Methyl-2-fluoroaniline|CS-W013511

Structure of 1978-38-7

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General Information

  • CAS No. 1978-38-7
  • Cat. No. CS-W013511
  • Purity ≥98%
  • MDL No. MFCD00028030
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FN
  • Molecular Weight 125.15
  • Synonym(s) 2-Fluoro-N-methylaniline
  • SMILES CNC1=CC=CC=C1F

Description

N-Methyl-2-fluoroaniline features a fluorinated aromatic ring paired with a methylamino substituent, delivering enhanced electron density at the para-position. This combination enables efficient coupling reactions in pharmaceutical synthesis and facilitates selective functionalization under mild conditions. The molecule exhibits good stability and solubility in common organic solvents, simplifying handling in multi-step transformations.

Application

N-Methyl-2-fluoroaniline serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated aromatic amine motifs into drug candidates. Its ortho-fluorine substituent enhances metabolic stability and modulates electronic properties, while the N-methyl group improves lipophilicity and membrane permeability. The compound exhibits good bench stability and reacts predictably in standard coupling, electrophilic substitution, and reductive amination protocols, facilitating efficient synthesis of complex heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.8674
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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