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Structure of 1978-37-6
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3-Fluoro-N-methylaniline features a fluorinated aromatic ring paired with a tertiary amine group, offering enhanced electron density and improved solubility in organic media. This bench-stable compound serves as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, where its ortho-directing fluoro substituent enables regioselective functionalization.
3-Fluoro-N-methylaniline serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds through standard coupling reactions. Its ortho-fluorine substituent supports directed metalation and facilitates regioselective functionalization. The N-methyl group enhances metabolic stability and modulates basicity, improving membrane permeability—features advantageous in drug discovery workflows. This compound exhibits bench stability, ease of handling, and compatibility with common purification techniques.
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GHS Pictogram :
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GHS No : GHS02,GHS05,GHS06
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Signal Word : Danger
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UN#: 1992
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Class : 3 (6.1)
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Packing Group : Ⅲ
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Hazard Statements : H226-H301-H318-H412
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P270-P273-P280-P330-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: