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CS-W001157 4
Total: USD 88.00

3-Amino-2-fluorotoluene

  • CAS No. 1978-33-2

  • Cat. No. CS-W003289
  • Purity≥98%
  • MDL No.MFCD06410915

*For research and further manufacturing use only, not for direct human use.

3-Amino-2-fluorotoluene|CS-W003289

Structure of 1978-33-2

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General Information

  • CAS No. 1978-33-2
  • Cat. No. CS-W003289
  • Purity ≥98%
  • MDL No. MFCD06410915
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FN
  • Molecular Weight 125.14
  • Synonym(s) Benzenamine, 2-fluoro-N-methyl-
  • SMILES Fc1c(C)cccc1N

Description

3-Amino-2-fluorotoluene is a fluorinated aromatic amine featuring a strategically positioned amino group adjacent to a fluorine substituent. This electronic and steric arrangement enhances its reactivity in cross-coupling and electrophilic substitution processes. The molecule exhibits excellent bench stability and solubility in common organic solvents, enabling seamless integration into synthetic workflows for pharmaceutical intermediates and functional materials.

Application

3-Amino-2-fluorotoluene serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-fluoro and amino groups provide complementary reactivity for sequential functionalization, while the methyl group offers a handle for further derivatization. The compound exhibits good bench stability and is compatible with common reaction conditions, facilitating efficient synthesis of complex heterocycles and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.71632
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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