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CS-W001157 4
Total: USD 88.00

Methyl 2-fluoro-4-hydroxybenzoate

  • CAS No. 197507-22-5

  • Cat. No. CS-W008400
  • Purity≥98%
  • MDL No.MFCD09038282

*For research and further manufacturing use only, not for direct human use.

Methyl 2-fluoro-4-hydroxybenzoate|CS-W008400

Structure of 197507-22-5

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General Information

  • CAS No. 197507-22-5
  • Cat. No. CS-W008400
  • Purity ≥98%
  • MDL No. MFCD09038282
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₃
  • Molecular Weight 170.14
  • Synonym(s) 2-Fluoro-4-hydroxybenzoic acid methyl ester
  • SMILES FC1=C(C(=O)OC)C=CC(=C1)O

Description

Methyl 2-fluoro-4-hydroxybenzoate features a strategically positioned fluorine atom and hydroxyl group on the aromatic ring, enabling precise electronic tuning and enhanced solubility in polar solvents. This combination facilitates direct incorporation into bioactive scaffolds and supports efficient derivatization under standard coupling conditions.

Application

Methyl 2-fluoro-4-hydroxybenzoate serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. The ortho-fluoro and para-hydroxy groups provide complementary reactivity for Suzuki-Miyaura coupling, nucleophilic substitution, and directed ortho-metalation. Its bench-stable nature, combined with straightforward purification via recrystallization, supports reliable use in multi-step syntheses and scale-up processes.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.3179
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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