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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-methoxybenzoic acid

  • CAS No. 394-42-3

  • Cat. No. CS-W002640
  • Purity≥98%
  • MDL No.MFCD00509373
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-methoxybenzoic acid|CS-W002640

Structure of 394-42-3

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Description

2-Fluoro-4-methoxybenzoic acid delivers a strategically positioned fluorine atom and methoxy group that enhance metabolic stability and lipophilicity in bioactive molecule design. This electron-withdrawing combination improves binding affinity in kinase inhibitors and other pharmaceutical scaffolds. The carboxylic acid functionality enables direct coupling or derivatization under standard amide formation conditions.

Application

2-Fluoro-4-methoxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via standard esterification, amide coupling, or Suzuki-Miyaura cross-coupling reactions. Its orthogonal functional groups—fluorine for metabolic stability and methoxy for electronic modulation—facilitate fine-tuning of physicochemical properties. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step synthesis workflows.

General Information

  • CAS No. 394-42-3
  • Cat. No. CS-W002640
  • Purity ≥98%
  • MDL No. MFCD00509373
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₃
  • Molecular Weight 170.14
  • Synonym(s) 2-Fluoro-p-anisic Acid
  • SMILES O=C(O)C1=CC=C(OC)C=C1F

Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.5325
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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