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Structure of 394-42-3
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2-Fluoro-4-methoxybenzoic acid delivers a strategically positioned fluorine atom and methoxy group that enhance metabolic stability and lipophilicity in bioactive molecule design. This electron-withdrawing combination improves binding affinity in kinase inhibitors and other pharmaceutical scaffolds. The carboxylic acid functionality enables direct coupling or derivatization under standard amide formation conditions.
2-Fluoro-4-methoxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via standard esterification, amide coupling, or Suzuki-Miyaura cross-coupling reactions. Its orthogonal functional groups—fluorine for metabolic stability and methoxy for electronic modulation—facilitate fine-tuning of physicochemical properties. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: