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CS-W001157 4
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3-(Pyrrolidin-1-yl)propan-1-ol

  • CAS No. 19748-66-4

  • Cat. No. CS-W005320
  • Purity≥96%
  • MDL No.MFCD01687769

*For research and further manufacturing use only, not for direct human use.

3-(Pyrrolidin-1-yl)propan-1-ol|CS-W005320

Structure of 19748-66-4

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General Information

  • CAS No. 19748-66-4
  • Cat. No. CS-W005320
  • Purity ≥96%
  • MDL No. MFCD01687769
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅NO
  • Molecular Weight 129.20
  • Synonym(s) 1-Pyrrolidinepropanol
  • SMILES OCCCN1CCCC1

Description

3-(Pyrrolidin-1-yl)propan-1-ol features a pyrrolidine ring linked to a flexible hydroxyalkyl chain, delivering enhanced solubility and nucleophilicity. This structure facilitates integration into bioactive molecules and enables efficient coupling in synthetic transformations under standard conditions.

Application

3-(Pyrrolidin-1-yl)propan-1-ol serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient incorporation of both amine and hydroxyl functionalities. Its pyrrolidine moiety enhances solubility and bioavailability, while the primary alcohol facilitates derivatization via esterification or ether formation. The compound exhibits excellent bench stability and is compatible with standard coupling protocols, making it a practical choice for synthesizing targeted heterocyclic scaffolds and peptide conjugates.

Synthesis

  • Route1
    • null|null
      123-75-1
    • In-stock
      3-Bromopropan-1-ol|CS-W007337
      627-18-9
    • ~95%
    • In-stock
      3-(Pyrrolidin-1-yl)propan-1-ol|CS-W005320
      19748-66-4

    References

    • BANYU PHARMACEUTICAL CO., LTD. Patent: EP1852423 A1, 2007 ; Location in patent: Page/Page column 6; 14 ; EP 1852423 A1
  • Route2
    • null|null
      123-75-1
    • null|null
      627-30-5
    • ~69%
    • In-stock
      3-(Pyrrolidin-1-yl)propan-1-ol|CS-W005320
      19748-66-4

    References

    • Hennequin, Laurent Francois Andre Patent: US2003/212055 A1, 2003 ;
  • Route3
    • Methyl 3-pyrrolidinopropionate|CS-0030357
      22041-21-0
    • ~93%
    • In-stock
      3-(Pyrrolidin-1-yl)propan-1-ol|CS-W005320
      19748-66-4

    References

    • Le Sann, Christine; Huddleston, Jonathan; Mann, John Tetrahedron, 2007 , vol. 63, # 52 p. 12903 - 12911

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   0.4646
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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