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Structure of 19715-49-2
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4-(Dimethylamino)benzenesulfonyl chloride features a strongly electron-donating dimethylamino group that enhances reactivity in nucleophilic substitution, enabling efficient sulfonamide formation. The sulfonyl chloride moiety provides a robust handle for conjugation under mild conditions. This compound serves as a key intermediate in the synthesis of bioactive sulfonamides and fluorescent probes.
4-(Dimethylamino)benzenesulfonyl chloride serves as a versatile sulfonylating agent for the synthesis of sulfonamide derivatives. Its electron-donating dimethylamino group enhances reactivity in nucleophilic substitution, enabling efficient coupling with amines and alcohols under mild conditions. The reagent exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in medicinal chemistry and process development workflows involving sulfonamide-based scaffolds.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: