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Structure of 196497-48-0
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Synthesized via serine palmitoyltransferase-catalyzed condensation of palmitic acid with glycine, 1-deoxysphinganine (CAS 196497-48-0) undergoes aberrant metabolism to form cytotoxic 1-deoxyceramides, disrupting sphingolipid homeostasis in neural and metabolic tissues.
1-deoxysphinganine (CAS 196497-48-0) drives cytotoxicity profiling in MN9D dopaminergic neuroblastoma cells through complex formation with bovine serum albumin, enabling precise neurotoxicity assessment. This setup streamlines screening of sphingolipid-related cell death pathways. Researchers leverage it as a targeted neurotoxic agent in human CD8+ T cells to study immune-mediated neuronal damage mechanisms.
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Lot numbers can be found on the outside label of a product: