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CS-W001157 4
Total: USD 88.00

4'-Trifluoromethylbiphenyl-4-carboxylic acid

  • CAS No. 195457-71-7

  • Cat. No. CS-W003063
  • Purity≥98%
  • MDL No.MFCD03424606

*For research and further manufacturing use only, not for direct human use.

4'-Trifluoromethylbiphenyl-4-carboxylic acid|CS-W003063

Structure of 195457-71-7

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General Information

  • CAS No. 195457-71-7
  • Cat. No. CS-W003063
  • Purity ≥98%
  • MDL No. MFCD03424606
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₉F₃O₂
  • Molecular Weight 266.22
  • Synonym(s) 4'-Trifluoromethyl-biphenyl-4-carboxylic acid
  • SMILES OC(=O)c1ccc(cc1)c1ccc(cc1)C(F)(F)F

Description

4'-Trifluoromethylbiphenyl-4-carboxylic acid features a biphenyl scaffold bearing a trifluoromethyl group at the para position of one phenyl ring and a carboxylic acid at the opposite end. This electron-deficient aryl moiety integrates readily into cross-coupling reactions and serves as a key building block in pharmaceutical and materials chemistry.

Application

4'-Trifluoromethylbiphenyl-4-carboxylic acid serves as a valuable building block in the synthesis of functionalized biaryl scaffolds, offering enhanced metabolic stability and lipophilicity due to the trifluoromethyl group. Its carboxylic acid functionality enables straightforward derivatization via amide, ester, or acyl chloride formation, facilitating integration into pharmaceutical intermediates and materials chemistry applications. The compound exhibits good bench stability and is compatible with standard coupling reactions.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   4.0706
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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