Lot numbers can be found on the outside label of a product:
(R)-tert-Butyl 3-formylpiperidine-1-carboxylate
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CAS No. 194726-46-0
- Cat. No. CS-0154727
- Purity≥97%
- MDL No.MFCD09953771
*For research and further manufacturing use only, not for direct human use.
Structure of 194726-46-0
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General Information
- CAS No. 194726-46-0
- Cat. No. CS-0154727
- Purity ≥97%
- MDL No. MFCD09953771
- Storage -20°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₉NO₃
- Molecular Weight 213.27
- Synonym(s) tert-Butyl (R)-3-formylpiperidine-1-carboxylate
- SMILES CC(C)(C)OC(=O)N1CCC[C@H](C1)C=O
Description
(R)-tert-Butyl 3-formylpiperidine-1-carboxylate features a chiral piperidine core with a formyl group at the 3-position, offering a bench-stable, moisture-tolerant scaffold for asymmetric synthesis. This building block integrates readily into diverse molecular architectures through selective functionalization at the aldehyde site, enabling efficient access to bioactive alkaloid derivatives and pharmaceutical intermediates.
Application
(R)-tert-Butyl 3-formylpiperidine-1-carboxylate serves as a versatile chiral building block for the synthesis of bioactive piperidine derivatives. The formyl group enables direct functionalization via nucleophilic addition, while the tert-butyl carbamate provides robust protection and facile deprotection under mild acidic conditions. Its bench-stable nature and compatibility with standard coupling and reductive amination protocols make it ideal for medicinal chemistry applications requiring stereocontrolled access to pharmacologically relevant scaffolds.
Synthesis
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Route1
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In-stock
116574-71-1 - ~96%
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In-stock
194726-46-0
References
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ELI LILLY AND COMPANY Patent: WO2005/118531 A1, 2005 ; Location in patent: Page/Page column 74 ; WO 2005/118531 A1
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Route2
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In-stock
934423-10-6 - ~%
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In-stock
194726-46-0
References
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PanThera Biopharma, LLC Patent: US2010/286125 A1, 2010 ; Location in patent: Page/Page column 30 ;
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Route3
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In-stock
194726-40-4 - ~%
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In-stock
194726-46-0
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254905-64-1
References
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Novo Nordisk A/S Patent: US6919315 B1, 2005 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS08,GHS09
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Signal Word : Danger
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UN#: 3082
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H319-H335-H372-H410
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Precautionary Statements : P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362-P391-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 46.61
- LogP 1.8324
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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