Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate

  • CAS No. 194726-40-4

  • Cat. No. CS-W010168
  • Purity≥98%
  • MDL No.MFCD07374389

*For research and further manufacturing use only, not for direct human use.

(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate|CS-W010168

Structure of 194726-40-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 194726-40-4
  • Cat. No. CS-W010168
  • Purity ≥98%
  • MDL No. MFCD07374389
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₃NO₄
  • Molecular Weight 257.33
  • Synonym(s) Ethyl (R)-1-Boc-nipecotate
  • SMILES O=C(N1C[C@H](C(OCC)=O)CCC1)OC(C)(C)C

Description

(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate is a stereochemically defined piperidine derivative featuring a bench-stable, moisture-tolerant diester scaffold. This chiral building block integrates readily into asymmetric synthesis workflows, offering predictable stereoselectivity in downstream functionalization. The tert-butyl and ethyl ester groups enable selective deprotection and coupling reactions under mild conditions.

Application

(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate serves as a versatile chiral building block in medicinal chemistry, enabling stereoselective synthesis of piperidine-based scaffolds. The protected diamine core exhibits excellent bench stability and functional group tolerance, facilitating downstream transformations including reductive amination, amide coupling, and transition-metal-catalyzed cross-couplings. Its orthogonal protection profile supports sequential derivatization, making it ideal for constructing complex heterocyclic motifs in API development.

Synthesis

  • Route1
    • null|null
      917112-58-4
    • ~%
    • In-stock
      (R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate|CS-W010168
      194726-40-4

    References

    • European Journal of Organic Chemistry, , # 19 p. 4343 - 4347
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 21 p. 3235 - 3238
  • Route3

    References

    • European Journal of Organic Chemistry, , # 19 p. 4343 - 4347

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   55.84
  • LogP   2.1966
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 194726-40-4 sigma194726-40-4 manufacturer194726-40-4 price194726-40-4 structure194726-40-4 SDSbuy 194726-40-4194726-40-4 supplier194726-40-4 uses194726-40-4 molecular weightprice of 194726-40-4194726-40-4 chemical name formula of 194726-40-4
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label