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CS-W001157 4
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3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-amine hydrochloride

  • CAS No. 1946817-21-5

  • Cat. No. CS-0343126
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-amine hydrochloride|CS-0343126

Structure of 1946817-21-5

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General Information

  • CAS No. 1946817-21-5
  • Cat. No. CS-0343126
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈ClF₂N₃
  • Molecular Weight 183.59
  • Synonym(s) None
  • SMILES FC(C1=NN(C)C=C1N)F.Cl

Description

This difluoromethyl-substituted pyrazole integrates a sterically accessible methylated amine handle, enabling direct functionalization in late-stage diversification. The hydrochloride salt enhances solubility and stability under standard bench conditions, facilitating use in synthetic organic chemistry workflows requiring polar, electron-deficient heterocyclic scaffolds.

Application

3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-amine hydrochloride serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group adjacent to a pyrazole nitrogen. The compound exhibits enhanced metabolic stability and favorable lipophilicity, facilitating its use in the synthesis of bioactive heterocycles. Its amine functionality supports straightforward derivatization via coupling reactions, while the hydrochloride salt ensures improved crystallinity and shelf stability for routine bench handling.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   1.3617
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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