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tert-Butyl 4-((5-bromopyridin-2-yl)oxy)piperidine-1-carboxylate

  • CAS No. 194668-49-0

  • Cat. No. CS-0146101
  • Molecule weight357.24
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-((5-bromopyridin-2-yl)oxy)piperidine-1-carboxylate|CS-0146101

Structure of 194668-49-0

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General Information

  • CAS No. 194668-49-0
  • Cat. No. CS-0146101
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₁BrN₂O₃
  • Molecular Weight 357.24
  • Synonym(s) TERT-BUTYL 4-[(5-BROMOPYRIDIN-2-YL)OXY]PIPERIDINE-1-CARBOXYLATE
  • SMILES O=C(N1CCC(OC2=NC=C(Br)C=C2)CC1)OC(C)(C)C

Description

tert-Butyl 4-((5-bromopyridin-2-yl)oxy)piperidine-1-carboxylate is a bench-stable, moisture-tolerant building block featuring a brominated pyridine handle and a protected piperidine scaffold. The para-bromo group enables direct cross-coupling reactions, while the tert-butoxycarbonyl moiety provides orthogonal protection for amine functionalization. This structure facilitates rapid access to bioactive heterocycles in medicinal chemistry workflows.

Application

tert-Butyl 4-((5-bromopyridin-2-yl)oxy)piperidine-1-carboxylate serves as a versatile building block for the synthesis of functionalized piperidine derivatives. The bromopyridine moiety enables palladium-catalyzed cross-coupling reactions, while the tert-butyl carbamate group provides stability and facilitates selective deprotection under mild acidic conditions. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex heterocyclic scaffolds in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   51.66
  • LogP   3.6224
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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