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CS-W001157 4
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6-Bromo-[1,2,4]triazolo[4,3-a]pyrazine

  • CAS No. 1935422-57-3

  • Cat. No. CS-0309516
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-[1,2,4]triazolo[4,3-a]pyrazine|CS-0309516

Structure of 1935422-57-3

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General Information

  • CAS No. 1935422-57-3
  • Cat. No. CS-0309516
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrN₄
  • Molecular Weight 199.01
  • Synonym(s) None
  • SMILES BrC1=CN2C(C=N1)=NN=C2

Description

6-Bromo-[1,2,4]triazolo[4,3-a]pyrazine is a heterocyclic building block featuring a brominated triazolopyrazine core. This electron-deficient scaffold integrates readily into synthetic sequences, enabling direct functionalization via cross-coupling. The bromine substituent facilitates palladium-catalyzed transformations, while the fused ring system provides rigidity and enhanced metabolic stability. Ideal for medicinal chemistry and materials science applications.

Application

6-Bromo-[1,2,4]triazolo[4,3-a]pyrazine serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its bromine substituent enables palladium-catalyzed cross-coupling reactions, facilitating the construction of biaryl and alkylated derivatives. The fused triazolopyrazine core exhibits excellent bench stability and functional group tolerance, making it well-suited for modular synthesis workflows in API development and advanced material design.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   43.08
  • LogP   0.8868
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   0

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