tert-Butyl 7-amino-1H-indole-1-carboxylate

Name: tert-Butyl 7-amino-1H-indole-1-carboxylate
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CAS No. 1934432-59-3
Cat. No. CS-0163055
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl 7-amino-1H-indole-1-carboxylate|CS-0163055

Structure of 1934432-59-3

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General Information

CAS No. 1934432-59-3
Cat. No. CS-0163055
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₆N₂O₂
Molecular Weight 232.28
Synonym(s) None
SMILES O=C(N1C=CC2=C1C(N)=CC=C2)OC(C)(C)C

Description

tert-Butyl 7-amino-1H-indole-1-carboxylate features a bench-stable indole core with a strategically positioned amino group at the C7 position, enabling direct functionalization in late-stage diversification. The tert-butyl ester serves as a robust protecting group for the carboxylic acid, readily cleaved under mild acidic conditions without affecting sensitive heterocyclic moieties. This derivative supports efficient access to complex indole-based architectures in medicinal chemistry and materials synthesis.

Application

tert-Butyl 7-amino-1H-indole-1-carboxylate serves as a versatile building block for indole-based scaffolds, enabling direct functionalization at the 7-position. The tert-butyl carbamate group provides excellent stability and ease of removal under mild acidic conditions, while the primary amine facilitates coupling reactions and derivatization. This compound is well-suited for medicinal chemistry campaigns requiring access to substituted indoles via standard reductive amination, Buchwald-Hartwig, or electrophilic substitution protocols.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 57.25
LogP 3.0067
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aromatic heterocycle compounds Indole compounds

Key Words

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tert-Butyl 7-amino-1H-indole-1-carboxylate

CAS No. 1934432-59-3

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