Tert-butyl n-(4-amino-2-methoxyphenyl)carbamate

Name: Tert-butyl n-(4-amino-2-methoxyphenyl)carbamate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 190851-19-5
Cat. No. CS-0249303
Molecule weight238.28
Purity≥95%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Tert-butyl n-(4-amino-2-methoxyphenyl)carbamate|CS-0249303

Structure of 190851-19-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 190851-19-5
Cat. No. CS-0249303
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₈N₂O₃
Molecular Weight 238.28
Synonym(s) tert-Butyl (4-amino-2-methoxyphenyl)carbamate
SMILES O=C(OC(C)(C)C)NC1=CC=C(N)C=C1OC

Description

Tert-butyl N-(4-amino-2-methoxyphenyl)carbamate features a protected aniline scaffold with a methoxy group at the ortho position, enhancing solubility and stability. This bench-stable derivative enables direct incorporation into peptide coupling sequences and serves as a key intermediate in the synthesis of bioactive arylamines.

Application

Tert-butyl N-(4-amino-2-methoxyphenyl)carbamate serves as a versatile protected amine intermediate in medicinal chemistry synthesis. The tert-butyl carbamate group provides excellent bench stability and orthogonal deprotection under mild acidic conditions. The 4-amino-2-methoxyphenyl moiety enables direct coupling reactions for constructing biologically relevant scaffolds, including kinase inhibitors and CNS-targeted compounds. Functional group tolerance supports subsequent derivatization via amide formation, Suzuki coupling, or electrophilic substitution, making it a practical building block for lead optimization campaigns.

Synthesis

Route1
- In-stock
  
  911365-00-9
- ~92%
- In-stock
  
  190851-19-5
References
- Kim, Hwan Myung; An, Myoung Jin; Hong, Jin Hee; Jeong, Byeong Ha; Kwon, Ohyun; Hyon, Ju-Yong; Hong, Seok-Cheol; Lee, Kyoung J.; Cho, Bong Rae Angewandte Chemie - International Edition, 2008 , vol. 47, # 12 p. 2231 - 2234

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 73.58
LogP 2.6244
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

190851-19-5 sigma190851-19-5 manufacturer190851-19-5 price190851-19-5 structure190851-19-5 SDSbuy 190851-19-5190851-19-5 supplier190851-19-5 uses190851-19-5 molecular weightprice of 190851-19-5190851-19-5 chemical name formula of 190851-19-5

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Tert-butyl n-(4-amino-2-methoxyphenyl)carbamate

CAS No. 190851-19-5

Recommended Products