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CS-W001157 4
Total: USD 88.00

3-Bromo-4-methoxyaniline

  • CAS No. 19056-41-8

  • Cat. No. CS-W007436
  • Purity≥98%
  • MDL No.MFCD04094339

*For research and further manufacturing use only, not for direct human use.

3-Bromo-4-methoxyaniline|CS-W007436

Structure of 19056-41-8

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General Information

  • CAS No. 19056-41-8
  • Cat. No. CS-W007436
  • Purity ≥98%
  • MDL No. MFCD04094339
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrNO
  • Molecular Weight 202.05
  • Synonym(s) 4-Amino-2-bromoanisole
  • SMILES NC1=CC=C(OC)C(Br)=C1

Application

3-Bromo-4-methoxyaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted anilines via palladium-catalyzed cross-coupling reactions. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the methoxy substituent enhances solubility and modulates electronic properties. Its bench-stable crystalline form allows for straightforward handling and purification, making it well-suited for multi-step synthetic sequences requiring functional group compatibility and predictable reactivity.

Synthesis

  • Route1

    References

    • Cambridge Enterprise Limited; Kapadnis, Prashant Bhimrao; Glen, Robert; Hiley, Robin; Bell, James; Spring, David Patent: US2013/53372 A1, 2013 ; Location in patent: Paragraph 0584; 0585 ;
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      3-Bromo-4-methoxyaniline|CS-W007436
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    References

    • PROLYSIS LTD Patent: WO2009/74812 A1, 2009 ; Location in patent: Page/Page column 84; 85 ; WO 2009/074812 A1
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      3-Bromo-4-methoxyaniline|CS-W007436
      19056-41-8

    References

    • Merck and Co., Inc. Patent: US5929094 A1, 1999 ; US 5929094 A

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.0399
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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