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Structure of 190273-94-0
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6-(Trifluoromethyl)quinazolin-2-amine integrates a trifluoromethyl group at the 6-position of the quinazoline scaffold, enhancing electron-withdrawing character and metabolic stability. This moiety enables direct incorporation into kinase inhibitor scaffolds, offering improved membrane permeability and target engagement in medicinal chemistry campaigns.
6-(Trifluoromethyl)quinazolin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to kinase-inhibitor scaffolds. Its trifluoromethyl group enhances metabolic stability and membrane permeability, while the quinazoline core facilitates robust coupling reactions. The amine functionality supports direct derivatization and salt formation, offering improved solubility and handling—ideal for high-throughput synthesis and lead optimization workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: