3-Chloro-2,6-difluorobenzaldehyde

Name: 3-Chloro-2,6-difluorobenzaldehyde
Brand: ChemScene
Availability: InStock
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CAS No. 190011-87-1
Cat. No. CS-W016013
Purity≥98%
MDL No.MFCD01631323

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Chloro-2,6-difluorobenzaldehyde|CS-W016013

Structure of 190011-87-1

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General Information

CAS No. 190011-87-1
Cat. No. CS-W016013
Purity ≥98%
MDL No. MFCD01631323
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃ClF₂O
Molecular Weight 176.55
Synonym(s) 3-chloro-2,6-difluoro-benzaldehyde
SMILES O=CC1=C(F)C=CC(Cl)=C1F

Description

3-Chloro-2,6-difluorobenzaldehyde features a trifluorinated aromatic core with orthogonal electron-withdrawing substituents that enhance electrophilicity at the carbonyl carbon. This configuration enables efficient coupling in cross-coupling reactions and facilitates rapid functionalization in pharmaceutical intermediates. The molecule exhibits excellent stability under standard handling conditions and demonstrates favorable solubility in common organic solvents.

Application

3-Chloro-2,6-difluorobenzaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated aromatic scaffolds. Its orthogonal reactivity profile—driven by the electron-withdrawing chloro and difluoro substituents—facilitates nucleophilic addition, cross-coupling, and condensation reactions under standard conditions. The compound exhibits excellent bench stability and is readily purified via flash chromatography, making it well-suited for scalable synthesis of bioactive molecules and pharmaceutical intermediates.

Synthesis

Route1
- 1435-44-5
- ~%
- In-stock
  
  190011-87-1
References
- US6342497 B1, ; Page column 32 ;
Route2
- In-stock
  
  4394-85-8
- 109-72-8
- 1435-44-5
- ~%
- In-stock
  
  190011-87-1
References
- US5883102 A1, ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 17.07
LogP 2.4307
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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3-Chloro-2,6-difluorobenzaldehyde

CAS No. 190011-87-1

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