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CS-W001157 4
Total: USD 88.00

Pivaloyloxymethyl chloride

  • CAS No. 18997-19-8

  • Cat. No. CS-W018522
  • Purity≥98%
  • MDL No.MFCD00000884

*For research and further manufacturing use only, not for direct human use.

Pivaloyloxymethyl chloride|CS-W018522

Structure of 18997-19-8

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General Information

  • CAS No. 18997-19-8
  • Cat. No. CS-W018522
  • Purity ≥98%
  • MDL No. MFCD00000884
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁ClO₂
  • Molecular Weight 150.60
  • Synonym(s) None
  • SMILES CC(C)(C)C(OCCl)=O

Description

Chloromethyl pivalate reacts with sodium salt of sulbactam to yield sulbactam pivoxil. It undergoes acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to yield bis(pivaloyloxymethyl) PMEA.Chloromethyl pivalate was used in the synthesis of pivaloyloxy methyl ester of ofloxacin as prodrug. It was used as the reagent during the synthesis of an isoindoline-annulated, tricyclic sultam library via microwave-assisted, continuous-flow organic synthesis.

Synthesis

  • Route1
    • null|null
      50-00-0
    • null|null
      3282-30-2
    • ~70%
    • In-stock
      Pivaloyloxymethyl chloride|CS-W018522
      18997-19-8

    References

    • Iyer; Yu; Ho; Agrawal Synthetic Communications, 1995 , vol. 25, # 18 p. 2739 - 2749
  • Route2
    • null|null
      74-97-5
    • In-stock
      Sodium pivalate|CS-W006398
      1184-88-9
    • ~56%
    • In-stock
      Pivaloyloxymethyl chloride|CS-W018522
      18997-19-8

    References

    • SHIONOGI SEIYAKU KABUSHIKI KAISHA Patent: EP406660 A1, 1991 ;
  • Route3
    • null|null
      74-97-5
    • In-stock
      Potassium pivalate|CS-W022935
      19455-23-3
    • ~21%
    • In-stock
      Pivaloyloxymethyl chloride|CS-W018522
      18997-19-8

    References

    • SHIONOGI SEIYAKU KABUSHIKI KAISHA Patent: EP406660 A1, 1991 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 3272
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H302+H312+H332-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.772
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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