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CS-W001157 4
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Tetramethyl methylenebis(phosphonate)

  • CAS No. 16001-93-7

  • Cat. No. CS-0316451
  • Purity≥96%
  • MDL No.MFCD00014884

*For research and further manufacturing use only, not for direct human use.

Tetramethyl methylenebis(phosphonate)|CS-0316451

Structure of 16001-93-7

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General Information

  • CAS No. 16001-93-7
  • Cat. No. CS-0316451
  • Purity ≥96%
  • MDL No. MFCD00014884
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₄O₆P₂
  • Molecular Weight 232.11
  • Synonym(s) Tetramethyl methylenediphosphonate
  • SMILES COP(=O)(CP(=O)(OC)OC)OC

Description

Tetramethyl methylenebis(phosphonate) features a symmetric methylene bridge flanked by two phosphonate ester groups, delivering enhanced stability and solubility in organic media. This structure enables efficient coordination in metal complexation and serves as a robust ligand in catalytic systems requiring durable phosphorus-based functionality.

Application

Tetramethyl methylenebis(phosphonate) serves as a versatile bisphosphonate building block for the synthesis of phosphonate-containing heterocycles and functionalized organic frameworks. Its four methyl groups provide enhanced stability and ease of purification, while the bisphosphonate moiety enables reliable coupling reactions and metal coordination. This compound functions effectively in standard organophosphorus transformations, facilitating access to complex molecular architectures with high reproducibility in synthetic workflows.

Synthesis

  • Route1
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      75-15-0
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      868-85-9
    • ~%
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      1112-38-5
    • In-stock
      Tetramethyl methylenebis(phosphonate)|CS-0316451
      16001-93-7

    References

    • Heuze; Lemarie; Vazeux; Gulea; Masson; Sene; Jaffres; Alberti; MacCiantelli Phosphorus, Sulfur and Silicon and the Related Elements, 2009 , vol. 184, # 4 p. 820 - 829
  • Route2
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      186581-53-3
    • In-stock
      Medronic acid|CS-0028208
      1984-15-2
    • ~%
    • In-stock
      Tetramethyl methylenebis(phosphonate)|CS-0316451
      16001-93-7

    References

    • Brophy,J.J.; Gallagher,M.J. Australian Journal of Chemistry, 1967 , vol. 20, p. 503 - 513
  • Route3
    • In-stock
      Medronic acid|CS-0028208
      1984-15-2
    • null|null
      149-73-5
    • ~%
    • In-stock
      Tetramethyl methylenebis(phosphonate)|CS-0316451
      16001-93-7

    References

    • Nicholson,D.A. et al. Journal of Organic Chemistry, 1970 , vol. 35, p. 3149 - 3150 Full Text View citing articles Show Details McKenna, Charles E.; Khawli, Leslie A.; Ahmad, Wan-Yaacob; Pham, Phuong; Bongartz, Jean-Pierre Phosphorus and Sulfur and the Related Elements, 1988 , vol. 37, p. 1 - 12

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   71.06
  • LogP   1.9157
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   6

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