Lot numbers can be found on the outside label of a product:
1-Boc-4-Methylpiperidine-4-carboxylic acid
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CAS No. 189321-63-9
- Cat. No. CS-M0704
- Purity≥97%
- MDL No.MFCD02179132
*For research and further manufacturing use only, not for direct human use.
Structure of 189321-63-9
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General Information
- CAS No. 189321-63-9
- Cat. No. CS-M0704
- Purity ≥97%
- MDL No. MFCD02179132
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₂₁NO₄
- Molecular Weight 243.30
- Synonym(s) 1-N-Boc-4-Methyl-Piperidine-4-Carboxylic Acid
- SMILES O=C(OC(C)(C)C)N1CCC(C(O)=O)(C)CC1
Description
1-Boc-4-Methylpiperidine-4-carboxylic acid features a sterically hindered piperidine core with a stable Boc-protected carboxylic acid moiety, enabling direct incorporation into peptide and macrocyclic scaffolds. The methyl group enhances conformational rigidity, while the bench-stable protection simplifies handling and purification under standard conditions.
Application
1-Boc-4-methylpiperidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of piperidine-based scaffolds with enhanced metabolic stability. The Boc group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. Its methylated C4 position imparts conformational rigidity, while the carboxylic acid functionality supports efficient coupling reactions, making it ideal for peptide and macrocycle assembly.
Synthesis
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Route1
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In-stock
189442-87-3 - ~92%
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In-stock
189321-63-9
References
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PURDUE PHARMA L.P.; SHIONOGI and CO., LTD. Patent: WO2008/89201 A2, 2008 ; Location in patent: Page/Page column 234 ; WO 2008/089201 A2
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Route2
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296240-48-7 - ~93%
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In-stock
189321-63-9
References
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TORAY INDUSTRIES, INC. Patent: EP2009006 A1, 2008 ; Location in patent: Page/Page column 79 ;
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Route3
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In-stock
724790-59-4 - ~57%
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In-stock
189321-63-9
References
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TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R. Patent: WO2013/19621 A1, 2013 ; Location in patent: Page/Page column 57; 58 ; WO 2013/019621 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 66.84
- LogP 2.1082
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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