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CS-W001157 4
Total: USD 88.00

5-Chloro-2-methylpyrazolo[1,5-a]pyrimidine

  • CAS No. 189116-36-7

  • Cat. No. CS-W004252
  • Purity≥98%
  • MDL No.MFCD17676711

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-methylpyrazolo[1,5-a]pyrimidine|CS-W004252

Structure of 189116-36-7

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General Information

  • CAS No. 189116-36-7
  • Cat. No. CS-W004252
  • Purity ≥98%
  • MDL No. MFCD17676711
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClN₃
  • Molecular Weight 167.60
  • Synonym(s) 332382-54-8
  • SMILES CC1=NN2C=CC(Cl)=NC2=C1

Description

5-Chloro-2-methylpyrazolo[1,5-a]pyrimidine features a fused heterocyclic core with electron-withdrawing chlorine and methyl substituents, enabling robust integration into kinase inhibitor scaffolds. This bench-stable, moisture-tolerant compound pairs efficiently with palladium-catalyzed cross-coupling reactions, delivering high-yield access to diverse pharmacophores in medicinal chemistry workflows.

Application

5-Chloro-2-methylpyrazolo[1,5-a]pyrimidine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its chlorine atom at C5 provides a reliable site for nucleophilic substitution, while the methyl group enhances metabolic stability and modulates electronic properties. The scaffold exhibits excellent bench stability, facilitates straightforward purification, and functions effectively in diverse reaction environments relevant to API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   1.69112
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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