2-(Difluoromethyl)pyridin-4-amine hydrochloride

Name: 2-(Difluoromethyl)pyridin-4-amine hydrochloride
Brand: ChemScene
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CAS No. 1890194-45-2
Cat. No. CS-0042624
Purity≥95%
MDL No.MFCD30489143

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-(Difluoromethyl)pyridin-4-amine hydrochloride|CS-0042624

Structure of 1890194-45-2

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General Information

CAS No. 1890194-45-2
Cat. No. CS-0042624
Purity ≥95%
MDL No. MFCD30489143
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClF₂N₂
Molecular Weight 180.58
Synonym(s) 4-Amino-2-(difluoromethyl)pyridine HCL
SMILES NC1=CC(C(F)F)=NC=C1.[H]Cl

Description

This difluoromethylpyridine derivative features a pyridin-4-amine core bearing a strategically positioned difluoromethyl group, enhancing metabolic stability and modulating electronic properties. The hydrochloride salt form improves solubility and handling under standard bench conditions, enabling straightforward integration into synthetic workflows for medicinal chemistry and materials science applications.

Application

2-(Difluoromethyl)pyridin-4-amine hydrochloride serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group adjacent to a pyridine nitrogen. The amine functionality facilitates facile derivatization via amidation, alkylation, or coupling reactions, while the difluoromethyl moiety imparts enhanced metabolic stability and modulated lipophilicity. Bench-stable and readily purified, it functions efficiently in standard synthetic workflows for heterocyclic scaffold elaboration.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 2.0232
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-(Difluoromethyl)pyridin-4-amine hydrochloride

CAS No. 1890194-45-2

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