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CS-W001157 4
Total: USD 88.00

Methyl N-Boc-4-hydroxypiperidine-2-carboxylate

  • CAS No. 187753-13-5

  • Cat. No. CS-D0875
  • Purity≥96%
  • MDL No.MFCD08437533

*For research and further manufacturing use only, not for direct human use.

Methyl N-Boc-4-hydroxypiperidine-2-carboxylate|CS-D0875

Structure of 187753-13-5

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General Information

  • CAS No. 187753-13-5
  • Cat. No. CS-D0875
  • Purity ≥96%
  • MDL No. MFCD08437533
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₅
  • Molecular Weight 259.30
  • Synonym(s) None
  • SMILES OC1CCN(C(OC(C)(C)C)=O)C(C(OC)=O)C1

Description

Methyl N-Boc-4-hydroxypiperidine-2-carboxylate features a bench-stable Boc-protected piperidine scaffold with a strategically positioned hydroxyl group. This configuration enables direct functionalization at C4 while maintaining compatibility with standard deprotection and coupling protocols in peptide and medicinal chemistry workflows.

Application

Methyl N-Boc-4-hydroxypiperidine-2-carboxylate serves as a versatile building block in medicinal chemistry, enabling the synthesis of piperidine-based scaffolds prevalent in bioactive molecules. The Boc-protected amine and ester functionalities offer orthogonal reactivity, facilitating selective transformations. Its bench-stable nature and compatibility with standard coupling and reduction protocols make it ideal for iterative synthesis workflows.

Synthesis

  • Route1
    • Methyl 4-hydroxypiperidine-2-carboxylate|CS-0006440
      144913-66-6
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • ~88%
    • In-stock
      Methyl N-Boc-4-hydroxypiperidine-2-carboxylate|CS-D0875
      187753-13-5

    References

    • WO2004/14902 A2, ; Page 46 ; WO 2004/014902 A2
  • Route2
    • null|null
      1391042-08-2
    • ~47%
    • In-stock
      Methyl N-Boc-4-hydroxypiperidine-2-carboxylate|CS-D0875
      187753-13-5

    References

    • Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, , vol. 67, # 4 p. 373 - 388
  • Route3
    • null|null
      5382-16-1
    • ~%
    • In-stock
      Methyl N-Boc-4-hydroxypiperidine-2-carboxylate|CS-D0875
      187753-13-5

    References

    • Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, , vol. 67, # 4 p. 373 - 388

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   76.07
  • LogP   0.9198
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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