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CS-W001157 4
Total: USD 88.00

3-Cyclopropyl-4-methyl-1H-pyrazole-5-carboxylic acid

  • CAS No. 1867157-28-5

  • Cat. No. CS-0073829
  • Purity≥95%
  • MDL No.MFCD20535329

*For research and further manufacturing use only, not for direct human use.

3-Cyclopropyl-4-methyl-1H-pyrazole-5-carboxylic acid|CS-0073829

Structure of 1867157-28-5

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General Information

  • CAS No. 1867157-28-5
  • Cat. No. CS-0073829
  • Purity ≥95%
  • MDL No. MFCD20535329
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂O₂
  • Molecular Weight 166.18
  • Synonym(s) None
  • SMILES O=C(O)C1=C(C)C(C2CC2)=NN1

Description

This pyrazole carboxylic acid features a sterically constrained cyclopropyl group and a methyl substituent at the 3- and 4-positions, respectively, enhancing metabolic stability. The electron-deficient pyrazole core enables efficient coupling in synthetic transformations, while the carboxylic acid functionality facilitates derivatization and conjugation under standard conditions.

Application

3-Cyclopropyl-4-methyl-1H-pyrazole-5-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its pyrazole core exhibits robust bench stability and tolerates a range of functional groups, enabling direct derivatization via amide formation, esterification, or decarboxylation. The carboxylic acid functionality facilitates conjugation in peptide coupling protocols and supports integration into API scaffolds through standard synthetic transformations.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.29372
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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