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CS-W001157 4
Total: USD 88.00

(2-Amino-4-(trifluoromethyl)phenyl)methanol

  • CAS No. 186602-93-7

  • Cat. No. CS-0139442
  • Purity≥98%
  • MDL No.MFCD17215842

*For research and further manufacturing use only, not for direct human use.

(2-Amino-4-(trifluoromethyl)phenyl)methanol|CS-0139442

Structure of 186602-93-7

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General Information

  • CAS No. 186602-93-7
  • Cat. No. CS-0139442
  • Purity ≥98%
  • MDL No. MFCD17215842
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈F₃NO
  • Molecular Weight 191.15
  • Synonym(s) 2-amino-4-(trifluoromethyl)benzyl alcohol
  • SMILES OCC1=CC=C(C(F)(F)F)C=C1N

Description

This bench-stable arylmethanol features a para-trifluoromethyl group and an ortho-amino functionality, enabling direct incorporation into pharmaceutical scaffolds. The amino group facilitates derivatization, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity in bioactive molecules.

Application

(2-Amino-4-(trifluoromethyl)phenyl)methanol serves as a valuable building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds and functionalized arylamines. Its amine and alcohol functionalities offer orthogonal reactivity for derivatization, while the trifluoromethyl group imparts metabolic stability and enhanced lipophilicity. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in iterative synthetic sequences and API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H290-H318
Precautionary Statements : P234-P280-P390-P406

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.7799
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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