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CS-W001157 4
Total: USD 88.00

H-D-HoPro-OMe.HCl

  • CAS No. 18650-38-9

  • Cat. No. CS-D1721
  • Purity≥97%
  • MDL No.MFCD00237412

*For research and further manufacturing use only, not for direct human use.

H-D-HoPro-OMe.HCl|CS-D1721

Structure of 18650-38-9

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General Information

  • CAS No. 18650-38-9
  • Cat. No. CS-D1721
  • Purity ≥97%
  • MDL No. MFCD00237412
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄ClNO₂
  • Molecular Weight 179.64
  • Synonym(s) N,N,N-tributylbutan-1-aminium benzoate
  • SMILES O=C([C@@H]1NCCCC1)OC.[H]Cl

Description

H-D-HoPro-OMe.HCl features a stable, moisture-tolerant proline-derived scaffold with a methyl ester group enabling efficient downstream derivatization. This bench-stable building block integrates seamlessly into peptide synthesis workflows, offering enhanced solubility and compatibility under standard conditions.

Application

H-D-HoPro-OMe.HCl serves as a stable, bench-friendly building block for the synthesis of proline-derived heterocycles and peptidomimetics. Its N-protected, O-methylated structure facilitates selective functionalization and orthogonal reactivity in complex molecule assembly, enabling efficient access to bioactive scaffolds commonly found in medicinal chemistry campaigns.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      D-Pipecolinic acid|CS-D1144
      1723-00-8
    • ~97%
    • In-stock
      H-D-HoPro-OMe.HCl|CS-D1721
      18650-38-9

    References

    • Xia, Guangxin; Liu, Lin; Liu, Haiyan; Yu, Jianxin; Xu, Zhenmin; Chen, Qian; Ma, Chen; Li, Ping; Xiong, Bing; Liu, Xuejun; Shen, Jingkang ChemMedChem, 2013 , vol. 8, # 4 p. 577 - 581
  • Route2

    References

    • Tetrahedron Letters, , vol. 31, # 16 p. 2341 - 2344
  • Route3
    • null|null
      67-56-1
    • In-stock
      Boc-D-HoPro-OH|CS-W014189
      28697-17-8
    • ~%
    • In-stock
      H-D-HoPro-OMe.HCl|CS-D1721
      18650-38-9

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 9 p. 2711 - 2714

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   0.7233
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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