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CS-W001157 4
Total: USD 88.00

2,3,5-Trichloroaniline

  • CAS No. 18487-39-3

  • Cat. No. CS-0060180
  • Purity≥97%
  • MDL No.MFCD04114058

*For research and further manufacturing use only, not for direct human use.

2,3,5-Trichloroaniline|CS-0060180

Structure of 18487-39-3

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General Information

  • CAS No. 18487-39-3
  • Cat. No. CS-0060180
  • Purity ≥97%
  • MDL No. MFCD04114058
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄Cl₃N
  • Molecular Weight None
  • Synonym(s) 2,3,5-Trichlorobenzenamine
  • SMILES C1=C(C=C(C(=C1Cl)Cl)N)Cl

Description

2,3,5-Trichloroaniline is a chlorinated aromatic amine featuring three chlorine atoms at the 2, 3, and 5 positions of the aniline ring. This electron-deficient scaffold enables direct coupling in cross-coupling reactions and serves as a key intermediate in agrochemical and pharmaceutical synthesis. The molecule exhibits enhanced stability under standard conditions and integrates readily into complex molecular architectures.

Application

2,3,5-Trichloroaniline serves as a valuable building block in the synthesis of pharmaceutical intermediates and agrochemicals. Its electron-deficient aromatic ring enables efficient coupling reactions, while the primary amine group facilitates derivatization via acylation, diazotization, or Ullmann-type couplings. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in scalable synthetic workflows.

Synthesis

  • Route1
    • null|null
      626-43-7
    • ~49%
    • In-stock
      2,3,5-Trichloroaniline|CS-0060180
      18487-39-3

    References

    • Hovander; Malmberg; Athanasiadou; Athanassiadis; Rahm; Bergman; Wehler, E. Klasson Archives of Environmental Contamination and Toxicology, 2002 , vol. 42, # 1 p. 105 - 117
  • Route2

    References

    • Hodgson; Kershaw Journal of the Chemical Society, 1929 , p. 2918; Journal of the Chemical Society, 1930 , p. 1419
  • Route3

    References

    • Hodgson; Kershaw Journal of the Chemical Society, 1929 , p. 2918; Journal of the Chemical Society, 1930 , p. 1419

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08,GHS09
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331-H373-H400-H410
Precautionary Statements : P260-P261-P264-P270-P271-P273-P280-P301+P310-P302+P352-P304+P340-P311-P312-P314-P330-P361-P363-P391-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   3.229
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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